Reduction of 1-phenyl-2-(2-pyridyl)-1,2-ethanedione with 1-benzyl-1,4-dihydronicotinamide in acetonitrile in the presence of zinc perchlorate has been studied. The α-diketone coordinates onto zinc ion through its pyridine-ring nitrogen and benzene-side carbonyl oxygen, whereas the reduction takes place on pyridine-side carbonyl group. It is concluded that an effective ligand to a metal ion is not necessarily a facile substrate of the reduction.
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Ohno et al. (1980) studied this question.
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