Key result
Seasonal trivalent inactivated influenza vaccines by CSL Biotherapies might have caused two to three hospital admissions for febrile convulsions for every influenza admission prevented.
Why the study?
Does seasonal trivalent inactivated influenza vaccine cause more hospital admissions for febrile convulsions than it prevents for influenza in children aged six months to four years?
Observational
Does seasonal trivalent inactivated influenza vaccine cause more hospital admissions for febrile convulsions than it prevents for influenza in children aged six months to four years?
The CSL trivalent inactivated influenza vaccine in children under five was associated with a higher risk of hospital admission for febrile convulsions than the benefit of preventing influenza admissions.
Answers are grounded in this paper and cite their sources.
May warrant caution with CSL TIV in young children; leaves open risk-benefit of other influenza vaccines.
Australian and New Zealand health authorities identified seasonal trivalent inactivated influenza vaccines manufactured by CSL Biotherapies as the probable cause of increased febrile convulsions in children under five within 24 hours of vaccination and recommended against their use in this age group. We quantified the benefit-risk profile of the CSL vaccines using the number needed to vaccinate and suggest they might have caused two to three hospital admissions due to febrile convulsions for every hospital admission due to influenza prevented.
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Kelly et al. (2010) conducted an observational in Influenza / Febrile convulsions. Seasonal trivalent inactivated influenza vaccine (CSL Biotherapies) was evaluated on Ratio of hospital admissions due to febrile convulsions to hospital admissions due to influenza prevented (2 to 3 febrile convulsion admissions per influenza admission prevented). Seasonal trivalent inactivated influenza vaccines by CSL Biotherapies might have caused two to three hospital admissions for febrile convulsions for every influenza admission prevented.
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