Key result
Aluminum oxide nanoparticles induced acute kidney injury in mice and synergistically exacerbated nephrotoxicity when co-administered with cisplatin or 5-aminosalicylic acid.
Why the study?
Aluminum oxide nanoparticles are widely used industrially, but their potential biological hazards and drug interactions had not been addressed.
Does intravenous administration of aluminum oxide nanoparticles alone or co-administered with cisplatin or 5-aminosalicylic acid induce acute kidney or liver injury in mice?
Does intravenous administration of aluminum oxide nanoparticles alone or co-administered with cisplatin or 5-aminosalicylic acid induce acute kidney or liver injury in mice?
Intravenous administration of aluminum oxide nanoparticles induces acute kidney injury in mice, which is synergistically exacerbated when co-administered with cisplatin or 5-aminosalicylic acid.
Alerts to nAlO nephrotoxicity risk with cisplatin co-exposure; leaves open human safety translation.
The use of nanoparticles in various industrial fields is increasing. Aluminum oxide nanoparticles (nAlO) exhibit excellent functionality and are thus widely used for industrial purposes. However, the potential biological hazards of nAlO have not been addressed. Therefore, we investigated the in vivo effects and drug interactions of nAlO. Administration of nAlO to mice via the tail vein induced acute kidney injury but not liver injury. nAlO induced kidney injury when co-administered with cisplatin or 5-aminosalicylic acid. Thus, our results indicate that nAlO exhibits potential nephrotoxicity either alone or through drug interactions.
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Araki et al. (2025) studied Acute kidney injury. Aluminum oxide nanoparticles (nAlO) vs. Vehicle control was evaluated on Blood urea nitrogen (BUN) and creatinine (Cre) levels (p=<0.05). Aluminum oxide nanoparticles induced acute kidney injury in mice and synergistically exacerbated nephrotoxicity when co-administered with cisplatin or 5-aminosalicylic acid.
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