Experimental Amyloidosis Using Silver Nitrate — Electron Microscopic Study on the Relationship Between Silver Granules, Amyloid Fibrils and Reticuloendothelial System —

Amyloidosis was experimentally induced in mice by repeated subcutaneous injections of silver nitrate solution. Deposition of silver granules was noted near the amyloid fibrils. The deposition was not prominent in the recently formed amyloid nodules, but abundant in the old nodules. It may be presumed that the deposition of silver granules among the amyloid fibrils suggests the filter‐like nature of amyloid fibrils which take various substances from the blood stream. From the relation of amyloid fibrils and silver granules, the amyloid bundles projecting from the Kupffer cell into the space of Disse were produced by the Kupffer cells and did not indicate the phagocytosis of amyloid by the cells. The mechanism of amyloidosis following injection of silver nitrate and the role of the lysosome of reticuloendothelial cells in the pathogenesis of amyloidosis have been discussed.