Key result
The fluorescent antinuclear test is more sensitive, while the LE cell test is more specific in the detection of the lupus erythematosus factor.
Why the study?
How does the fluorescent antinuclear (FA) test compare to LE cell tests in detecting the LE factor?
Observational
How does the fluorescent antinuclear (FA) test compare to LE cell tests in detecting the LE factor?
The fluorescent antinuclear test offers higher sensitivity, whereas the LE cell test provides higher specificity for diagnosing lupus erythematosus.
May inform test selection in suspected lupus; leaves open optimal strategy with current serologic methods.
The fluorescent antinuclear (FA) test for the lupus erythematosus (LE) factor tends to vary in its sensitivity with several steps involved in its performance. With leukocytes its sensitiity may be quite close to that of the LE clot procedure, although with nuclear material such as neonatal thyroid or tumor cells, its sensitivity is high. However, with the increased sensitivity there appears to be decreased specificity with this procedure. In spite of these limitations the fluorescent antinuclear factor test is a valuable aid in the diagnosis of lupus erythematosus and related auto-immune diseases. In brief, the fluorescent antinuclear test is the more sensitive and the LE cell tests the more specific in the detection of the LE factor.
No takes yet. Share an insight, caveat, or question.
WILLARD C. PETERSON (1966) conducted an observational in Lupus erythematosus and related auto-immune diseases. Fluorescent antinuclear (FA) test vs. LE cell tests (LE clot procedure) was evaluated on Sensitivity and specificity in the detection of the LE factor. The fluorescent antinuclear test is more sensitive, while the LE cell test is more specific in the detection of the lupus erythematosus factor.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: