Preclinical study reveals that albumin-binding domain addition extends tracer circulation in cancer models, indicating non-specific uptake that limits hypoxia quantification.
In]In-DTPA-B9 has a high affinity to CAIX and shows specific targeting to CAIX in head and neck cancer xenografts. The addition of ABD prolonged plasma half-life, increased tumor uptake, and enabled SPECT/CT imaging. This uptake was, however, partly CAIX- independent, precluding the ABD-tracers for use in hypoxia quantification in this tumor type.
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Lith et al. (2022) studied this question.
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