Opening Windows into Tumors

Delivery of nanoparticles to tumors is limited by vascular permeability and intratumoral diffusion. In this issue of ACS Nano, Jiang et al. show that the manipulation of tumor physiology using antiangiogenic therapy can improve the tumor penetration of quantum dots with 20 and 40 nm hydrodynamic diameters. This Perspective describes the problems, challenges, and perspectives of using antiangiogenic therapy in combination with nanometer-sized drugs and contrast agents in preclinical and clinical studies.