The Hodgkin's-like reticulum cell neoplasms of SJL/J mice are malignant by cytological criteria and by the criteria of invasiveness and dissemination. However, they show unusual transplantation behavior. Of 20 spontaneous tumors transplanted to SJL/J hosts, 9 grew progressively in from 17–100% of animals in the first generation. Of these, 5 have grown for 69,45,41,6, and 3 generations, but not always in 100% of the animals. One failed to grow in the 28th generation, and one in the second. Two grew in the first and second generation, respectively, but were not transplanted further. Evidence for tumor-specific antigens has been obtained by reinoculation of the tumors in animals in which the tumors had previously failed to grow. Among 20 animals in which tumor T5205 failed to grow, reinoculation was successful in only 1 animal as compared with control growth in 95% of mice that had never been tumor hosts. Similarly, in (C57BL × SJL)F1 mice, reinoculation of T5205 was unsuccessful in 32 mice as compared with control growth in 75%. T5633 grew on reinoculation in only 2 of 23 mice as compared with 91% in controls. T5418 grew on reinoculation in 7 of 38 mice as compared with 68% in controls. In contrast, when 15 animals that had failed to grow T5418 were then inoculated with T5205, the latter grew in 93%, suggesting the existence of more than one specific antigen among these tumors. There was a lowered incidence of new spontaneous tumors in mice that had rejected T5633 and T5205.
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Edwin D. Murphy (1969) studied this question.