Key result
Vitamin D deficiency was associated with significantly higher carotid intima-media thickness (0.75 vs 0.68 mm, P<0.05) and epicardial fat thickness (0.66 vs 0.56 cm, P<0.001) compared to controls.
Why the study?
Is Vitamin D deficiency associated with increased subclinical atherosclerosis markers (CIMT and EFT) in patients without cardiovascular disease?
Case-Control (n=134)
Is Vitamin D deficiency associated with increased subclinical atherosclerosis markers (CIMT and EFT) in patients without cardiovascular disease?
Vitamin D deficiency is associated with increased carotid intima-media thickness and epicardial fat thickness, suggesting a potential link to early subclinical atherosclerosis.
Answers are grounded in this paper and cite their sources.
VDD-associated CIMT/EFT increases should not yet change practice; hypothesis-generating for supplementation trials in atherosclerosis prevention.
PURPOSE: Patients with vitamin D deficiency (VDD) have potential to have increased cardiovascular morbidity and mortality. In this study, we aimed to discover the findings of early atherosclerosis in patients with VDD by measuring carotid intima-media thickness (CIMT) and epicardial fat thickness (EFT). MATERIALS AND METHODS: The study population includes 52 patients with VDD (n = 30 [57% female], mean ± SD age 54.28 ± 8.77 years, mean ± SD serum 25-hydroxyvitamin D (25 [OH] D) 11 ± 2.4 ng/mL) and 82 participants for control group (n = 52 [63.4% female], mean ± SD age 56.40 ± 7.90 years, mean ± SD serum (25 [OH] D) 53 ± 4.2 ng/mL) who have no cardiovascular disease. Carotid intima-media thickness was assessed by using ultrasonography, and EFT was measured on the free wall of the right ventricle at end diastole from the parasternal long-axis views by standard transthoracic 2-dimensional echocardiography. RESULTS: Both CIMT and EFT were significantly higher in patients with VDD compared with controls (0.75 ± 0.16 mm vs 0.68 ± 0.21 mm, P < 0.05, and 0.66 ± 0.15 cm vs 0.56 ± 0.15 cm, P < 0.001). CONCLUSIONS: Patients with VDD seem to have increased CIMT and EFT, which are predictors of atherosclerotic process. Further studies are needed to confirm these results.
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Aydın et al. (2018) conducted a case-control in Vitamin D deficiency (n=134). Vitamin D deficiency vs. Controls without vitamin D deficiency was evaluated on Carotid intima-media thickness (CIMT) (p=<0.05). Vitamin D deficiency was associated with significantly higher carotid intima-media thickness (0.75 vs 0.68 mm, P<0.05) and epicardial fat thickness (0.66 vs 0.56 cm, P<0.001) compared to controls.
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