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November 1, 1980Journal of Medicinal ChemistryOpen Access

Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids

Jürg R. Pfister Walter E. Wymann Janette M. Mahoney L. David Waterbury

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Abstract

A series of xanthone-2-carboxylic acids substituted in the 7 position with sulfamoyl and other groups was synthesized and assayed in vitro for inhibition of aldose reductase isolated from rabbit lenses. At a concentration of 10(-6) M, the N-methyl-N-(2-hydroxyethyl)sulfamoyl derivative 14 produced an 83% inhibition of aldose reductase. The structural requirements for this type of activity are discussed.

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Pfister et al. (1980) studied this question.

synapsesocial.com/papers/6aa01e25516c2ec66e7c7829 https://doi.org/10.1021/jm00185a027

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