Agents that induce differentiation of lens epithelial cells into lens fiber cells in vitro transiently stimulate the transmethylation of phosphatidylethanolamine. Inhibition of transmethylation by 3-deazaadenosine results in a corresponding inhibition of the cell elongation that characterizes lens fiber formation, suggesting that phospholipid methylation plays an essential role in the differentiation of these cells.
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Zelenka et al. (1982) studied this question.
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