A nucleophilic addition reaction to N-methylaldimines without acid or metal species is described. A novel reagent, dicyanomethyl acetate, is used as a nucleophile to give alpha-(N-methyl-N-acetyl)amino acid methyl esters in excellent yield.
No takes yet. Share an insight, caveat, or question.
Nemoto et al. (2005) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: