Key result
Low HDL-cholesterol levels (<0.90 mmol/l) were present in 50% of normolipidaemic men with CAD compared to 15% of controls, indicating it as a risk factor in normolipidaemia but not type IV.
Why the study?
Is low HDL-cholesterol concentration a risk indicator for coronary artery disease in normolipidaemic and hypertriglyceridaemic men?
Case-Control (n=155)
Is low HDL-cholesterol concentration a risk indicator for coronary artery disease in normolipidaemic and hypertriglyceridaemic men?
A low HDL-cholesterol level may serve as an additional risk factor for CAD development in normolipidaemic men, but not in those with type IV hyperlipoproteinaemia.
Low HDL may flag CAD risk in normolipidaemic men; supports association but leaves open prospective validation and clinical utility.
The aim was to investigate whether a low concentration of high density lipoprotein (HDL) may be used as a risk indicator in normolipidaemic (n.l.) subjects, and whether a reduced HDL concentration constitutes an additional risk factor in hyperlipoproteinaemia. Eighty-two men with angiographically documented coronary artery disease (CAD) were studied. The majority of the CAD men was either n.l. (n = 38) or had type IV hyperlipoproteinaemia (n = 22). These two groups were compared separately to one group of healthy n.l. subjects (n = 44), and one group of healthy subjects with type IV hyperlipoproteinaemia (n = 29). In about 50% of n.l. CAD men the HDL-cholesterol (HDL-C) was lower than the 15th percentile (0.90 mmol/l) of n.l. controls, and about 65% of n.l. CAD men had ratios of HDL-C/total plasma cholesterol (C) lower than 0.17, the 15th percentile of n.l. controls. Almost all type IV subjects had reduced HDL-C levels and decreased ratios of HDL-C/C, whether they had obvious CAD or not. Thus, in normolipidaemia, but not in type IV hyperlipoproteinaemia, a low HDL-C level may be used as an additional risk factor for CAD development.
No takes yet. Share an insight, caveat, or question.
Moberg et al. (1981) conducted a case-control in Coronary artery disease (n=155). Low HDL-cholesterol vs. Healthy controls was evaluated on HDL-cholesterol lower than 0.90 mmol/l (15th percentile of controls). Low HDL-cholesterol levels (<0.90 mmol/l) were present in 50% of normolipidaemic men with CAD compared to 15% of controls, indicating it as a risk factor in normolipidaemia but not type IV.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: