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ThiS and that: An alternative substrate for thiazole synthase, namely 1,4-dideoxy-D-xylulose-5-phosphate, was synthesized and used as a mechanistic probe to determine the regiochemistry of the acyl-shift reaction that occurs as an intermediate step in the biosynthesis of thiamin thiazole in B. subtilis (see scheme; ThiS protein (blue); ThiG protein (red); OP=phosphate group).
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Chatterjee et al. (2006) studied this question.
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