Key result
Acute hypoglycemia induced via glucose clamp significantly reduced hedonic tone (p=.001) and energetic arousal (p=.01), and increased tense arousal (p<.0005) compared to euglycemic control.
Why the study?
Does acute hypoglycemia alter mood states in nondiabetic human participants?
Population
24 nondiabetic human participants
Comparison
Acute hypoglycemia induced twice using a… vs Euglycemic placebo control study
Design
Other
Follow-up
60 min of controlled hypoglycemia and at least 30 min…
Authors
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Acute hypoglycemia may alter mood in nondiabetics; leaves open relevance to diabetes management and requires prospective confirmation.
RCT (n=24)
Does acute hypoglycemia alter mood states in nondiabetic human participants?
p-value: p = .001, p < .0005, p = .01
Acute hypoglycemia induces profound changes in mood, including reduced hedonic tone and increased tense arousal, which persist even after euglycemia is restored.
Gold et al. (1995) conducted an RCT in Healthy (n=24). Acute hypoglycemia (hyperinsulinemic glucose clamp) vs. Euglycemic placebo control was evaluated on Serial changes in mood assessed using the UWIST Mood Adjective Checklist (p=p = .001, p < .0005, p = .01). Acute hypoglycemia induced via glucose clamp significantly reduced hedonic tone (p=.001) and energetic arousal (p=.01), and increased tense arousal (p<.0005) compared to euglycemic control.
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