Key result
Trypanosoma cruzi infection reduced Caveolin-3 expression and activated ERK in cultured cardiac myocytes at 48 hours and in CD-1 mice at 66 days post-infection, normalizing by 180 days.
Why the study?
Does Trypanosoma cruzi infection alter Caveolin-3 expression and ERK activation in cardiac myocytes and mouse models?
Does Trypanosoma cruzi infection alter Caveolin-3 expression and ERK activation in cardiac myocytes and mouse models?
Trypanosoma cruzi infection reduces Caveolin-3 expression and activates ERK during the early phase of infection, potentially contributing to the pathogenesis of chagasic cardiomyopathy.
Early Caveolin-3/ERK changes may contribute to chagasic cardiomyopathy pathogenesis; leaves open human relevance and therapeutic targeting.
Caveolae are motile, membrane-bound compartments that contain a number of molecules that participate in cell signaling. Caveolins are protein markers of caveolae and function in a variety of biological processes. Caveolin-3 (Cav-3) is expressed in muscle cells and Cav-3 null mice display a cardiomyopathic phenotype. Ultrastructural cytochemistry, confocal microscopy and immunoblotting revealed a reduction in Cav-3 expression and an activation of ERK (extracellular-signal-regulated kinase) 48 hours after Trypanosoma cruzi infection of cultured cardiac myocytes. CD-1 mice infected with the Brazil strain of T. cruzi displayed reduced expression of Cav-3 and activation of ERK 66 days post infection (dpi). By 180 dpi there was a normalization of these values. These data suggest that the reduction in Cav-3 expression and the activation of ERK during the early phase of infection may contribute to the pathogenesis of chagasic cardiomyopathy.
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Adesse et al. (2010) studied Trypanosoma cruzi infection. Trypanosoma cruzi infection was evaluated on Caveolin-3 expression and ERK activation. Trypanosoma cruzi infection reduced Caveolin-3 expression and activated ERK in cultured cardiac myocytes at 48 hours and in CD-1 mice at 66 days post-infection, normalizing by 180 days.
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