Key result
IMODTM alone or in combination with exercise alleviated hyperglycemia, cardiac oxidative stress, and cardiac injury markers while elevating antioxidant enzyme activities in type 1 diabetic rats.
Why the study?
Reducing oxidative stress or increasing antioxidant levels may improve diabetic cardiomyopathy, prompting investigation into the effects of IMODTM and exercise on cardiac oxidative stress and antioxidants in diabetes.
Does IMODTM and exercise reduce cardiac oxidative stress and improve antioxidant balance in a rat model of type 1 diabetes?
Does IMODTM and exercise reduce cardiac oxidative stress and improve antioxidant balance in a rat model of type 1 diabetes?
IMODTM and exercise may improve diabetic cardiomyopathy by reducing oxidative stress and increasing antioxidant levels in a rat model.
Animal data suggest IMOD and exercise may mitigate diabetic cardiomyopathy; human trials needed before clinical consideration.
: Diabetes is a common metabolic disease that increases the risk of cardiovascular disease. It seems that the reduction of oxidative stress or increasing antioxidant levels improves diabetic cardiomyopathy. Antioxidant effects of immunomodulatory drug (IMODTM) and also beneficial influences of exercise on diabetic complications have been shown. The present study examined the effects of IMODTM and exercise on cardiac oxidative stress and antioxidants in diabetes. For this purpose, 64 rats were divided into 8 groups: control (C), exercise (E), IMODTM (20 mg/kg) (I), exercise plus IMODTM (E + I), diabetes (D), diabetic rats treated with exercise (D + E), diabetic rats treated with IMODTM (D + I), and diabetic rats treated with exercise plus IMODTM (D + E + I). Treatments with exercise and/or IMODTM were performed for 8 weeks. Type 1 diabetes was induced by intraperitoneal injection of 60 mg/kg streptozotocin. After the treatment period, all rats were anesthetized, and blood and heart samples were gathered for measurement of malondialdehyde (MDA) as an oxidative stress marker, lactate dehydrogenase (LDH) as a cardiac injury marker, total antioxidant capacity (TAC), and superoxide dismutase (SOD) as well as glutathione peroxidase (GPx) as antioxidant enzymes. The present study, for the first time, showed that IMODTM alone or in combination with exercise had positive effects on alleviating hyperglycemia, MDA, and LDH along with elevation of antioxidant enzymes activities in type 1 diabetic rats.
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Ali-Aghdam et al. (2020) studied Type 1 diabetes (n=64). IMODTM and exercise vs. Control and untreated diabetic rats was evaluated on Hyperglycemia, malondialdehyde (MDA), lactate dehydrogenase (LDH), and antioxidant enzymes. IMODTM alone or in combination with exercise alleviated hyperglycemia, cardiac oxidative stress, and cardiac injury markers while elevating antioxidant enzyme activities in type 1 diabetic rats.
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