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Prior to the availability of recombinant erythropoietin, virtually all kidney transplant recipients exhibited some degree of anemia in the early post‐transplant period, primarily as the consequence of operative blood loss and postoperative phlebotomies superimposed on a pre‐existing state of hypoerthyropoiesis characteristic of renal failure. Restoration of endogenous erythropoietin secretion by the renal allograft, now known to occur within hours to days after transplantation (1), generally led to correction of anemia within a period of 3–8 months (2), at least in patients with well‐functioning grafts.
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Donald E. Hricik (2003) studied this question.
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