Summary. A single subcutaneous injection of 10 or 50 μg of oestradiol cyclopentylpropionate (oecp) on Day 1 of the oestrous cycle induced luteolysis in cyclic guinea-pigs by Day 3. Regression of the corpora lutea was completed by Day 10. In addition to inducing luteolysis, a dose of 10 μg of oecp shortened the length of the cycle and also induced precocious ovulation between Days 9 and 12 of the cycle. A dose of 50 μg of oecp induced follicular atresia by Day 8. oecp was effective in causing luteolysis when injected on Days 1 or 4, but not on Day 6. Neither 5 mg of progesterone injected daily on Days 1 to 9 nor 1 mg of testosterone propionate injected on Day 1 induced luteolysis.
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Choudary et al. (1968) studied this question.
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