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Abstract [18F]AM694, [1‐(5‐[18F]fluoropentyl)‐1H‐indol‐3‐yl]‐(2‐iodophenyl)methanone, 1b, a potential radiotracer for imaging of cerebral cannabinoid receptor (CB1), has been synthesized by no‐carrier‐added regioselective radiofluorination of the corresponding tosylate. [18F]AM694 was obtained in 20% radiochemical yield (non‐decay‐corrected) with a specific activity of 14 500 mCi/µmol, a radiochemical purity of > 99%, and a chemical purity of 95.5%.
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Willis et al. (2003) studied this question.
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