Key result
Autoantibodies against G-protein-coupled receptors play a pathogenic role in cardiomyopathies and other diseases, presenting a target for treatments like immunoadsorption and aptamer neutralization.
Design
Review
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GPCR-AAB may drive functional autoantibody diseases; leaves open whether targeted removal alters outcomes in affected patients.
This review highlights the pathogenic role of GPCR autoantibodies in cardiomyopathies and evaluates various targeted immunomodulatory and removal therapies.
A 2018 study conducted a review in Functional autoantibody diseases (cardiomyopathies). GPCR-AAB targeted treatments was evaluated. Autoantibodies against G-protein-coupled receptors play a pathogenic role in cardiomyopathies and other diseases, presenting a target for treatments like immunoadsorption and aptamer neutralization.
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