The electrochemical response of sodium levothyroxine at carbon paste electrode in the presence of 0.1M HCl as supporting electrolyte was investigated by the cyclic voltammetry. It showed a well-defined oxidation peak at 0.78V and a sensitive and indiscernible reduction peaks at 0.53V and 0.32V. The effect of concentration and scan rate of sodium levothyroxine was studied. The scan rate effect showed the electrode process is adsorption controlled. The effect of surfactants like Sodium Dodecyl Sulfate (SDS), Cetyltrimethylammonium Bromide (CTAB), and TritonX-100 (TX-100) were studied by mobilizing and immobilizing methods. The concentration effect of all the three surfactants were studied. Among these SDS was showed excellent enhancement in both oxidation peak and reduction peak currents.
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Chitravathi et al. (2009) studied this question.
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