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Abstract —Properties of the histamine‐forming enzyme in rat brain were studied, utilizing a sensitive fluorometric assay. The optimum pH was related to substrate concentration and found to be6·4 at 10−2m‐histidine; the apparent Km was about 4·10−4m; enzyme activity was inhibited by α‐hydrazino ‐histidine and brocresine but was not affected by α‐methyl DOPA or benzene. These different data suggest that the 'specific’histidine decarboxylase (EC 4.1.1.22)—and not the aromatic l‐aminoacid decarboxylase—is involved. Determination of enzyme activity and histamine level in different areas of the rat brain revealed important regional differences, the two values being roughly parallel.
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Schwartz et al. (1970) studied this question.
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