Non-A, Non-B Hepatitis

Editorials1 July 1977Non-A, Non-B HepatitisBARUCH S. BLUMBERG, M.D.BARUCH S. BLUMBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-1-111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term "non-A, non-B hepatitis" is applied to cases of what appears to be viral hepatitis that cannot be identified as hepatitis A, hepatitis B or with the hepatitis associated with Epstein Barr virus and cytomegalovirus. A series of papers describing this variety of hepatitis (1-5), including several recently published clinical and epidemiologic studies (6-10), have helped in the understanding of the disease. Antibody to hepatitis A virus can be detected by an immune adherence hemagglutination assay using hepatitis A antigen purified from human stool. The presence of antibody implies previous infection. A rise in anti-HA titer in a serum...References1. FEINSTONE S, KAPIKIAN A, and PURCELL R: Transfusion-associated hepatitis not due to viral hepatitis type A or B. New Engl J Med 292:767-770, 1975 CrossrefMedlineGoogle Scholar2. ALTER H, PURCELL R, and HOLLAND P: Clinical and serological analysis of transfusion-associated hepatitis. Lancet 2:838-841, 1975 CrossrefMedlineGoogle Scholar3. PRINCE A, BROTMAN B, and GRADY G: Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis-B virus. Lancet 2:241-246, 1974 CrossrefMedlineGoogle Scholar4. VILLAREJOS V, VISONA K, and EDUARTE A: Evidence for viral hepatitis other than type A or type B among persons in Costa Rica. N Engl J Med 293:1350-1352, 1975 CrossrefMedlineGoogle Scholar5. MOSLEY J: Hepatitis types B and non-B. Epidemiologic background. JAMA 233:967-969, 1975 CrossrefMedlineGoogle Scholar6. DIENSTAG J, ALAAMA A, and MOSLEY J: The etiology of sporadic hepatitis B surface antigen-negative hepatitis. Ann Intern Med 87:1-6, 1977 LinkGoogle Scholar7. MEYERS J, DIENSTAG J, and PURCELL R: Parenterally transmitted non-A non-B hepatitis. An epidemic reassessed. Ann Intern Med 87:57-59, 1977 LinkGoogle Scholar8. HOOFNAGEL J, GERETY R, and TABOR E: Transmission of non-A, non-B hepatitis. Ann Intern Med 87:14-20, 1977 LinkGoogle Scholar9. DIENSTAG J, FEINSTONE S, and PURCELL R: Non-A, non-B post-transfusion hepatitis. Lancet 1:560-562, 1977 CrossrefMedlineGoogle Scholar10. SEEFF L, ZIMMERMAN H, and WRIGHT E: A randomized, double blind controlled trial of the efficacy of immune serum globulin for the prevention of post-transfusion hepatitis. Gastroenterology 72:111-121, 1977 CrossrefMedlineGoogle Scholar11. KRUGMAN S, GILES J, and HAMMOND J: Infectious hepatitis: evidence for two distinctive clinical, epidemiological, and immunologic types of infection. JAMA 200:365-373, 1967 CrossrefMedlineGoogle Scholar12. ALTER H, HOLLAND P, and PURCELL R: Post-transfusion hepatitis after exclusion of commercial and hepatitis-B antigen positive doners. Ann Intern Med 77:691-699, 1972 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BARUCH S. BLUMBERG, M.D.Affiliations: The Institute for Cancer Research Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdvancement of the Science and History of Cancer and Anticancer DrugsParacetamol overdose as a cause of non-A, non-B hepatitis.Recurrent Hepatitis Caused by Two Viruses Acquired Simultaneously during Blood TransfusionClinical Presentation of Nonhaemolytic Transfusion ReactionsHepatitis after the Transfusion of Frozen Red Cells and Washed Red CellsBlood Transfusion Therapy: Components, Indications, Complications and Controversies 1 July 1977Volume 87, Issue 1Page: 111-113KeywordsAntigensClinical epidemiologyHemagglutinationHepatitis AHepatitis A virusHepatitis B ePublished: 1 December 2008 Issue Published: 1 July 1977 PDF downloadLoading ...