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February 1, 1995Infection and ImmunityOpen Access

Attenuated live cholera vaccine strain CVD 103-HgR elicits significantly higher serum vibriocidal antibody titers in persons of blood group O

Rosanna Lagos A Avendaño V Prado I Horwitz S Wasserman G Losonsky Stanley J. Cryz James B. Kaper Myron M. Levine

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Abstract

Persons of blood group O are at increased risk of developing cholera gravis. In a randomized, placebo-controlled, double-blind safety-immunogenicity trial of live oral cholera vaccine CVD 103-HgR in 5- to 9-year-old Chilean children, vibriocidal antibody seroconversion (74% overall) did not differ by blood group. However, the reciprocal geometric mean titer (GMT) in blood group O vaccines (GMT = 486) was higher than that in non-O vaccines (GMT = 179) (P < 0.02).

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Lagos et al. (1995) studied this question.

synapsesocial.com/papers/6aa040d3e47507b78762857f https://doi.org/10.1128/iai.63.2.707-709.1995

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