Key result
MIT(1) potently contracts longitudinal ileal muscle and distal colon while relaxing proximal colon, binding with very high affinity to ileum and brain membranes.
MIT1 is a highly selective toxin that potently affects intestinal contractility and binds with high affinity to a receptor in the CNS and smooth muscle, potentially an unidentified K+ channel.
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Animal findings on MIT(1) gut effects and CNS binding should not alter practice; leaves open receptor identity and human relevance.
Schweitz et al. (1999) studied this question. MIT(1) (Mamba intestinal toxin) vs. 40 mM K(+) was evaluated on Intestinal contractility and membrane binding. MIT(1) potently contracts longitudinal ileal muscle and distal colon while relaxing proximal colon, binding with very high affinity to ileum and brain membranes.