Key result
Time-to-surgery >48 hours for elderly hip fractures did not increase complications or 30-day mortality, but significantly prolonged surgery-to-discharge time (HR 0.74; 95% CI 0.69-0.79; P<0.001).
Why the study?
Does earlier time-to-surgery (<48 hours) improve outcomes in elderly hip fracture patients compared to >48 hours?
Cohort (n=6,036)
Yes
Does earlier time-to-surgery (<48 hours) improve outcomes in elderly hip fracture patients compared to >48 hours?
In elderly hip fracture patients, delaying surgery beyond 48 hours does not increase 30-day mortality or complications after adjusting for comorbidities, but significantly increases hospital length of stay.
May not support delaying surgery >48 hours in elderly hip fractures; leaves open optimal timing pending prospective trials.
The morbidity and mortality after hip fracture in the elderly are influenced by non-modifiable comorbidities. Time-to-surgery is a modifiable factor that may play a role in postoperative morbidity. This study investigates the outcomes and complications in the elderly hip fracture surgery as a function of time-to-surgery. Using the American College of Surgeons-National Surgical Quality Improvement Program data from 2011 to 2012, a study population was generated using the Current Procedural Terminology codes for percutaneous or open treatment of femoral neck fractures (27235, 27236) and fixation with a screw and side plate or intramedullary fixation (27244, 27245) for peritrochanteric fractures. Three time-to-surgery groups (<24 hours to surgical intervention, 24-48 hours, and >48 hours) were created and matched for surgery type, sex, age, and American Society of Anesthesiologists class. Time-to-surgery was then studied for its effect on the post-surgical outcomes using the adjusted regression modeling. A study population of 6036 hip fractures was created, and 2012 patients were assigned to each matched time-to-surgery group. The unadjusted models showed that the earlier surgical intervention groups (<24 hours and 24-48 hours) exhibited a lower overall complication rate (P = .034) compared with the group waiting for surgery >48 hours. The unadjusted mortality rates increased with delay to surgical intervention (P = .039). Time-to-surgery caused no effect on the return to the operating room rate (P = .554) nor readmission rate (P = .285). Compared with other time-to-surgeries, the time-to-surgery of >48 hours was associated with prolonged total hospital length of stay (10.9 days) (P < .001) and a longer surgery-to-discharge time (hazard ratio, 95% confidence interval: 0.74, 0.69-0.79) (P < .001). Adjusted analyses showed no time-to-surgery related difference in complications (P = .143) but presented an increase in the total length of stay (P < .001) and surgery-to-discharge time (P < .001). Timeliness of surgical intervention in a comorbidity-adjusted population of elderly hip fracture patients causes no effect on the overall complications, readmissions, nor 30-day mortality. However, time-to-surgery of >48 hours is associated with costly increase in the total length of stay, including an increased post-surgery-to-discharge time.
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Alvi et al. (2018) conducted a cohort in Hip fracture (n=6,036). Time-to-surgery >48 hours vs. Time-to-surgery <48 hours was evaluated on Surgery-to-discharge time (HR 0.74, 95% CI 0.69-0.79, p=<.001). Time-to-surgery >48 hours for elderly hip fractures did not increase complications or 30-day mortality, but significantly prolonged surgery-to-discharge time (HR 0.74; 95% CI 0.69-0.79; P<0.001).
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