The addition of 1% pyruvate and fumarate to nutrient broth supported the growth of E. coli in the presence of 10 μg/ml of streptomycin. When the concentration of the acids was increased to 3%, growth took place even in the presence of 150 μg/ml of streptomycin. The streptomycin was not destroyed. The test bacteria growing in the presence of streptomycin and of the organic acids did not become resistant to streptomycin.
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Green et al. (1948) studied this question.