Overdispersion in COVID-19 increases the effectiveness of limiting nonrepetitive contacts for transmission control

Significance Evidence indicates that superspreading plays a dominant role in COVID-19 transmission, so that a small fraction of infected people causes a large proportion of new COVID-19 cases. We developed an agent-based model that simulates a superspreading disease moving through a society with networks of both repeated contacts and nonrepeated, random contacts. The results indicate that superspreading is the virus’ Achilles’ heel: Reducing random contacts—such as those that occur at sporting events, restaurants, bars, and the like—can control the outbreak at population scales.