Taxol, a true “evergreen” in natural product chemistry! Owing to the limited supply of this successful antitumor agent in the bark of yew trees, alternative sources are being sought. Crucial information on its unusual and complex biosynthesis (shown below) has been obtained, and some enzymes responsible have been identified. The long-term goal is the efficient, biotechnology production of taxol (1) by fungi or plant tissue cultures.
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Jürgen Rohr (1997) studied this question.
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