N-2-fluorenylacetamide (FAA) and its metabolic derivatives, N-hydroxy-N-2-fluorenylacetamide and N-acetoxy-N-2-fluorenyl-acetamide were studied in two cell systems: Chinese hamster for toxicity and mutagenicity and Syrian hamster (or toxicity and transformation. Cyto-toxicity (ratio of cloning efficiency of treated and control cells), mutagenicity (8-azaguanine-resistant colonies/105 cells), and transformation frequency (ratio of colonies exhibiting crisscross pattern to surviving treated colonies) increased with concentration and degree of reactivity of the derivative FAA.
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Huberman et al. (1972) studied this question.