Key result
Depressive symptoms after acute coronary syndrome were associated with elevated markers of inflammation (interleukin-17: β 0.047; 95% CI 0.010-0.083), endothelial dysfunction, and myocardial strain.
Why the study?
Are psychological constructs (depression, anxiety, optimism, gratitude) associated with markers of inflammation, endothelial function, and myocardial strain in post-ACS patients?
Cohort (n=164)
Are psychological constructs (depression, anxiety, optimism, gratitude) associated with markers of inflammation, endothelial function, and myocardial strain in post-ACS patients?
In post-ACS patients, depressive symptoms correlate with worse biomarker profiles for inflammation and myocardial strain, whereas positive psychological constructs like optimism and gratitude correlate with better endothelial function.
Depressive symptoms post-ACS link to adverse biomarkers; leaves open causality and whether interventions improve inflammation or strain.
OBJECTIVE: Psychological constructs are associated with cardiovascular health, but the biological mechanisms mediating these relationships are unknown. We examined relationships between psychological constructs and markers of inflammation, endothelial function, and myocardial strain in a cohort of post-acute coronary syndrome (ACS) patients. METHODS: Participants (N = 164) attended study visits 2 weeks and 6 months after ACS. During these visits, they completed self-report measures of depressive symptoms, anxiety, optimism, and gratitude; and blood samples were collected for measurement of biomarkers reflecting inflammation, endothelial function, and myocardial strain. Generalized estimating equations and linear regression analyses were performed to examine concurrent and prospective relationships between psychological constructs and biomarkers. RESULTS: In concurrent analyses, depressive symptoms were associated with elevated markers of inflammation (interleukin-17: β = .047; 95% confidence interval [CI] = .010-.083]), endothelial dysfunction (endothelin-1: β = .020; 95% [CI] = .004-.037]), and myocardial strain (N-terminal pro-B-type natriuretic peptide: β = .045; 95% [CI] = .008-.083]), independent of age, sex, medical variables, and anxiety, whereas anxiety was not associated with these markers in multivariable adjusted models. Optimism and gratitude were associated with lower levels of markers of endothelial dysfunction (endothelin-1: gratitude: β = -.009; 95% [CI] = -.017 to - .001]; optimism: β = -.009; 95% [CI] = -.016 to - .001]; soluble intercellular adhesion molecule-1: gratitude: β = -.007; 95% [CI] = -.014 to - .000]), independent of depressive and anxiety symptoms. Psychological constructs at 2 weeks were not prospectively associated with biomarkers at 6 months. CONCLUSIONS: Depressive symptoms were associated with more inflammation, myocardial strain, and endothelial dysfunction in the 6 months after ACS, whereas positive psychological constructs were linked to better endothelial function. Larger prospective studies may clarify the directionality of these relationships. CLINICAL TRIAL REGISTRATION: Clinicaltrials.gov identifier NCT01709669.
No takes yet. Share an insight, caveat, or question.
Celano et al. (2016) conducted a cohort in Acute coronary syndrome (ACS) (n=164). Psychological constructs (depressive symptoms, anxiety, optimism, gratitude) was evaluated on Markers of inflammation, endothelial function, and myocardial strain (β 0.047, 95% CI 0.010-0.083). Depressive symptoms after acute coronary syndrome were associated with elevated markers of inflammation (interleukin-17: β 0.047; 95% CI 0.010-0.083), endothelial dysfunction, and myocardial strain.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: