Divide and conquer: A novel approach was used to separate solvent effects from the intrinsic interactions involved in the association of biological complexes (see figure). The enthalpy of solvent reorganization for the formation of an intermolecular hydrogen bond in a biomolecular complex was determined by comparing the solution and gas-phase stabilities of structurally related complexes.
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Kitova et al. (2004) studied this question.
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