Preparation and Infusion of Cryoprecipitate from Exercised Donors

Summary. Factor‐VIII enriched cryoprecipitate was prepared by exercising donors on a bicycle ergometer. The mean increase in the activity of factor VIII was about 40%. The effect in vivo of post‐exercise cryoprecipitate was studied in patients with haemophilia A. The increment of factor VIII was only perceptible during the first hours after transfusion. This was due to a more rapid disappearance of factor VIII from the circulation, as was apparent by a shortened half‐survival time of the first phase of the biphasic disappearance curve.