Application of the ‘dual sorption’ model to drug transport through skin

The dual sorption theory has been extended to the transport of drug molecules through human skin in vitro . By assuming that sorption of drug molecules occurs by both dissolution and binding of drug to immobile sites in the skin, the experimental sorption isotherm can be predicted, and the disparity between steady state and time lag diffusivities can be reconciled. Furthermore, the dual sorption model has been used to develop techniques for controlling these sorption transport processes in order to rapidly achieve predictable transdermal drug delivery in vivo .