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Depending upon the oxidizing agent employed, various products are obtained from isatins (1): H2O2/glacial acetic acid leads to isatoic anhydrides (2), whereas H2S2O8/H2SO4 furnishes 2,3-dioxo-1,4-benzoxazines (3). Compound (1) is usually oxidized to (2) with the toxic chromium trioxide.
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REISSENWEBER et al. (1980) studied this question.
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