Reward for Persistence in Substance P Research

Substance P is a mammalian neurotransmitter that is involved in mediating a variety of conditions such as pain and anxiety. In his Perspective, Wahlestedt describes the history of pharmaceutical efforts directed toward developing substance P receptor antagonists. He goes on to discuss the new findings in this issue by Kramer et al. that suggest one of these antagonists may be useful in the treatment of depression.