The new cyclo/seco system (1)⇄(2) is accessible from the amide corresponding to (2) by removal of water. Product (1) is isolated and regenerates (2) on UV irradiation. For instance, (2), R1 = CH3, R2 = i-C3H7, can be kept for several days in THF at room temperature.
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Eckhardt et al. (1978) studied this question.
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