Key result
Elevated AST/ALT ratio linked to ~2-fold greater CLI risk in PAOD.
Why the study?
Does an elevated AST/ALT ratio (AAR > 1.67) associate with critical limb ischemia in patients with peripheral arterial occlusive disease?
Population
1782 patients with peripheral arterial occlusive disease treated at a single institution from 2005 to 2010…
Comparison
Elevated AST/ALT (De-Ritis) ratio (AAR > 1.67) vs AAR < 1.67
Design
Cross-sectional
Authors
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AAR may flag CLI risk in peripheral artery disease; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=1,782)
No
Does an elevated AST/ALT ratio (AAR > 1.67) associate with critical limb ischemia in patients with peripheral arterial occlusive disease?
Odds Ratio: 2 (95% CI 1.7–2.3)
Absolute Event Rate: 41.9% vs 23.8%
p-value: p=<0.001
An elevated AST/ALT ratio (>1.67) is a widely available and inexpensive marker significantly associated with critical limb ischemia in patients with peripheral arterial occlusive disease.
Rief et al. (2016) conducted a cross-sectional in Peripheral arterial occlusive disease (n=1,782). AST/ALT (De-Ritis) ratio > 1.67 vs. AST/ALT (De-Ritis) ratio < 1.67 was evaluated on Critical limb ischemia (CLI) (OR 2.0, 95% CI 1.7-2.3, p=<0.001). An AST/ALT ratio > 1.67 was independently associated with a 2-fold increased risk of critical limb ischemia (OR 2.0) in patients with peripheral arterial occlusive disease.
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