Key result
Treatment with unfractionated heparin, hysterectomy, and chemotherapy successfully suppressed the frequency and size of aseptic vegetation attached to the mitral valve in a patient with Trousseau syndrome.
Case Report (n=1)
No
Transthoracic echocardiography is a useful tool for monitoring the response of recurrent nonbacterial thrombotic endocarditis to unfractionated heparin and tumor reduction therapy in patients with Trousseau syndrome.
May support heparin plus tumor therapy for NBTE in Trousseau syndrome; hypothesis-generating from one case and requires prospective validation.
This paper aims to describe the usefulness of transthoracic echocardiography in the follow-up of recurrent nonbacterial thrombotic endocarditis (NBTE) associated with neoplastic conditions. A 60-year-old woman with advanced uterine cancer developed recurrent areas of aseptic vegetation on the mitral valve along with cerebral, renal and splenic embolisms. Echocardiographic assessments revealed vegetation and thrombotic events on three occasions. In this case, transthoracic echocardiography was effective in following the decreased frequency of attachment of the NBTE vegetation to the mitral valve and reductions in the size of the area of vegetation following treatment with unfractionated heparin infusion, hysterectomy and chemotherapy.
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Ito et al. (2013) conducted a case report in Trousseau Syndrome with Nonbacterial Thrombotic Endocarditis and Uterine Cancer (n=1). Unfractionated heparin, hysterectomy, and chemotherapy was evaluated on Resolution of vegetation and thromboembolic events. Treatment with unfractionated heparin, hysterectomy, and chemotherapy successfully suppressed the frequency and size of aseptic vegetation attached to the mitral valve in a patient with Trousseau syndrome.
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