The use of sodium hydrogen carbonate under solvent‐free conditions and microwave irradiation is by far the best method for N‐alkylating pyrazoles. The yields are good and the method is devoid of side reactions (quaternization, isomerization, hydrogen halide elimination). Solvent‐free conditions are the only ones that allow us to prepare 1‐substituted pyrazoles from secondary halides. The procedure using quaternary salts in one‐pot provides an interesting alternative for the preparation of 1‐heteroarylpyrazoles.
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Almena et al. (1998) studied this question.
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