Genomic Medicine and Endocrine Autoimmunity as Key to Mitochondrial Disease

The diabetes epidemic and the induction of various chronic diseases are expected to affect approx. 592 people by the year 2035. Diabetes and its connections to endocrine autoimmunity [1-3] has become important to metabolic disease with relevance to the non alcoholic fatty liver disease (NAFLD) epidemic and neurodegenerative diseases [4]. The urgency to prevent the largest diabetes epidemic in history has now assessed multiple risk factors involved with induction of Type 3 diabetes connected to various chronic diseases [4]. Interest in Type 3 diabetes has accelerated in the past 15 years with the critical importance of anti-aging genes [5,6] with relevance to autoimmune disease and mitophagy [7] and the global diabetes epidemic. The regulation of these genes is controlled by the heat shock gene Sirtuin 1 (Sirt 1) that is connected to appetite, immune and core body temperature regulation with relevance tomitophagy in NAFLD and metabolic disease.