Optical Isomers of Naftidrofuryl( = 2‐(Diethylamino)ethyl 2‐[(Naphth‐1‐yl)methyl]‐3‐(tetrahydrofur‐2‐yl)propanoate) The four optical isomers of naftidrofuryl (1) were prepared in two ways, by separation and resolution of the two diastereoisomeric racemates and by synthesis from the enantiomers of tetrahydrofuran‐2‐methanol (6); see Scheme}. The absolute configuration of one of the isomer as a tartrate monohydrate was established by X‐ray crystallography thus allowing the deduction of the absolute configurations of the other three optical isomers.
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DESCOURS et al. (1991) studied this question.
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