Synthetic-biological hybrids of biodegradable microparticles and transfected cells are assembled, as schematically illustrated in the figure. The cells are surface-functionalized with biotin and the particle surface is also engineered with biotin. Avidin is then used as a bridging protein to bind together the microparticles and the surface- functionalized cells.
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Krishnamachari et al. (2008) studied this question.
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