Key result
In Japanese patients with type 2 diabetes, low microalbuminuria was associated with a significantly higher risk of progression to overt proteinuria compared to normoalbuminuria (HR 8.45).
Cohort (n=1,558)
Yes
Hazard Ratio: 8.45 (95% CI 4.97–14.38)
Absolute Event Rate: 1.85% vs 0.23%
p-value: p=<0.01
In Japanese patients with type 2 diabetes, the transition rate from normo- or low microalbuminuria to overt proteinuria is low (0.67% annually), but is significantly accelerated by low microalbuminuria, poor glycemic control, higher systolic blood pressure, and smoking.
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Low microalbuminuria may flag higher progression risk in Japanese T2D; leaves open whether early intervention alters outcomes.
Katayama et al. (2011) conducted a cohort in Type 2 diabetes mellitus (n=1,558). Low microalbuminuria vs. Normoalbuminuria was evaluated on Progression to proteinuria (UACR >33.9 mg/mmol in two consecutive urine samples) (HR 8.45, 95% CI 4.97-14.38, p=<0.01). In Japanese patients with type 2 diabetes, low microalbuminuria was associated with a significantly higher risk of progression to overt proteinuria compared to normoalbuminuria (HR 8.45).
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