Key result
Acquired activated protein C resistance in patients with systemic lupus erythematosus was associated with increased rates of arterial thrombosis (24% vs 6%, P=0.04) and miscarriages (70% vs 32%, P=0.03).
Population
103 consecutive patients with systemic lupus erythematosus (SLE) and 103 matched controls
Design
Case-control
Authors
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May flag higher arterial thrombosis and miscarriage risk in SLE; hypothesis-generating and requires prospective confirmation before clinical adoption.
Case-Control (n=206)
Absolute Event Rate: 24% vs 6%
p-value: p=0.04
Acquired activated protein C resistance in patients with systemic lupus erythematosus is associated with an increased prevalence of arterial thrombosis and pregnancy losses.
Muñoz et al. (2002) conducted a case-control in Systemic lupus erythematosus (n=206). Acquired activated protein C resistance vs. Without acquired activated protein C resistance was evaluated on Arterial thrombosis (p=0.04). Acquired activated protein C resistance in patients with systemic lupus erythematosus was associated with increased rates of arterial thrombosis (24% vs 6%, P=0.04) and miscarriages (70% vs 32%, P=0.03).