Key result
Higher plasma Nogo-B levels are linked to a ~1% greater risk of CAD.
Why the study?
Does plasma Nogo-B level associate with the presence of coronary artery disease (ACS and SAP) compared to healthy controls?
Case-Control (n=120)
No
Does plasma Nogo-B level associate with the presence of coronary artery disease (ACS and SAP) compared to healthy controls?
Odds Ratio: 1.006 (95% CI 1–1.013)
p-value: p=0.047
Elevated Nogo-B associates with CAD; hypothesis-generating for biomarker utility, needs prospective validation before any clinical role.
Although the relationship between arteriosclerosis and inflammatory response has been recognized in recent years, little is known regarding the change in plasma Nogo-B in coronary artery disease (CAD). Thus, we investigated the expression levels of Nogo-B in CAD patients and examined this relation with disease stages. We recruited 92 CAD patients including 64 with acute coronary syndromes (ACS) and 28 with stable angina pectoris (SAP) cases and 28 healthy controls. The serum concentrations of Nogo-B were measured by enzyme-linked immunosorbent assay (ELISA). The plasma Nogo-B level was significantly higher in patients with ACS and SAP when compared with the healthy controls (both P < 0.05). Multivariate logistic regression analysis revealed that the level of Nogo-B was associated with CAD (odds ratio 1.006, 95% CI: 1.000-1.013, P < 0.05). In conclusion, an increased plasma Nogo-B level may be associated with CAD.
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Gao et al. (2015) conducted a case-control in Coronary artery disease (ACS and SAP) (n=120). Plasma Nogo-B level vs. Healthy controls was evaluated on Association of Nogo-B level with coronary artery disease (OR 1.006, 95% CI 1.000-1.013, p=0.047). Increased plasma Nogo-B levels were significantly associated with coronary artery disease (OR 1.006), with higher concentrations observed in patients with acute coronary syndromes and stable angina pectoris compared to healthy controls.
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