Nanomotor‐Based Strategy for Enhanced Penetration across Vasculature Model

Here the first nanomotor‐based strategy is reported to effectively cross tumor vasculature endothelium. The designed nanomotors are based on (poly(ethylene glycol)‐b‐polystyrene and poly(acrylic acid)‐b‐polystyrene) building blocks, which further self‐assemble into polymersomes of tunable sizes (100, 300 nm). The polymersomes are readily loaded with hydrophilic model drug into the aqueous compartment. A catalytic platinum cap is then partially deposited on the surface of the polymersome via electron beam evaporation, resulting in a polymersome Janus nanomotor. In a tumor vasculature model, these cargo‐loaded polymersome nanomotors demonstrate enhanced penetration across the endothelium.