Synthesis based on cyclohexadienes Part 36: an efficient methodology for the construction of spiro[4.5]decanes: a formal synthesis of acorone

This is the authors' abstract. We don't add key points for this paper.

An efficient strategy for the contruction of spiro[4.5]decanes is described and involves a bridgehead substitution of a methoxyl group by a methyl group followed by an oxidative cleavage of the tricyclo[5.2.2.0 1,5 ]undecane 25 to produce the spiro[4.5]decanes31 & 32 which are intermediates in the synthesis of acorone.A novel one-pot conversion of α-methoxy carboxylic acid to α-methyl carboxylic acid is described.