A new antioxidant and potent lipoxygenase (LOX) inhibitor, NC3B, was isolated from the fungus Aspergillus terreus and identified as 1, 3-dihydro-7-methyl-4, 5, 6-trihydroxy-isobenzofuran. Under weight gain method conditions with methyl linoleate as a substrate, NC3B was a stronger antioxidant than tocopherol (Toc) and acted as a weak Toc synergist during the autoxidation of methyl linoleate. NC3B significantly inhibited the oxidation of linoleic acid by sardine flesh LOX and caused reduction in oxygen uptake by the substrate.
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ISHIKAWA et al. (1996) studied this question.